Cgabryszek: Created page with "'''Class''' Short duration, depolarizing neuromuscular blocker '''Pharmacology and Actions''' # Succinylcholine is a short-acting, depolarizing skeletal muscle relaxant. ## Like acetylcholine, it combines with cholinergic receptors in the motor nerves to cause depolarization. ## Neuromuscular transmission is thus inhibited, which renders the muscles unable to be stimulated by acetylcholine. # Following IV/IO injection, complete paralysis is obtained within 60-90 secon..."

2022-04-04T03:59:30Z

Created page with "'''Class''' Short duration, depolarizing neuromuscular blocker '''Pharmacology and Actions''' # Succinylcholine is a short-acting, depolarizing skeletal muscle relaxant. ## Like acetylcholine, it combines with cholinergic receptors in the motor nerves to cause depolarization. ## Neuromuscular transmission is thus inhibited, which renders the muscles unable to be stimulated by acetylcholine. # Following IV/IO injection, complete paralysis is obtained within 60-90 secon..."

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'''Class'''

Short duration, depolarizing neuromuscular blocker

'''Pharmacology and Actions'''

# Succinylcholine is a short-acting, depolarizing skeletal muscle relaxant.
## Like acetylcholine, it combines with cholinergic receptors in the motor nerves to cause depolarization.
## Neuromuscular transmission is thus inhibited, which renders the muscles unable to be stimulated by acetylcholine.
# Following IV/IO injection, complete paralysis is obtained within 60-90 seconds and persists for approximately 4 to 5 minutes.
## Effects then start to fade, and a return to normal is usually seen within 6 minutes.
## Muscle relaxation begins in the eyelids and jaw.
## It then progresses to the limbs, the abdomen, and finally the diaphragm and intercostals.
# It has no effect on consciousness.

'''Indications'''

# Succinylcholine is indicated to achieve temporary paralysis when endotracheal intubation is indicated and muscle tone or seizure activity prevents it.

'''Contraindications'''

# Penetrating eye injury
# Patients at risk for hyperkalemia (e.g., patients with crush or bum injuries greater than 24 hours old, severe renal failure or known dialysis patient.)
# Known hypersensitivity to the drug.

'''Precautions'''

# Succinylcholine should not be administered unless personnel skilled in endotracheal intubation are present and ready to perform the procedure.
# Cardiac arrest and ventricular arrhythmias can occur when Succinylcholine is administered to patients with severe bums and severe crush injuries.

'''Administration'''

# Adult: 100 mg IV/IO push

'''Side Effects and Special Notes'''

# Oxygen therapies and suction should be readily available, as should all emergency resuscitative drugs and equipment.
# This agent has no effect on consciousness, cerebration or pain threshold. Thus, it is crucial that an analgesic or sedative is administered prior to Succinylcholine.
# When the airway is secured after Succinylcholine administration and intubation, and further need for neuromuscular blockade is indicated, consider the administration of rocuronium (Zemeron).
# This agent may increase intragastric pressure, which could result in vomiting and possible aspiration of stomach contents.
# Lidocaine administration, prior to paralytic administration, reduces the rise in ICP associated with paralytic endotracheal intubation. This is especially important if there is already the possibility of ICP secondary to a head injury.

SUCCINYLCHOLINE (ANECTINE) - Revision history