Cgabryszek: Created page with "'''Class''' Antihistamine '''Pharmacology and Actions''' # An antihistamine that blocks action of histamine released from the cells during an allergic reaction. # Direct CNS effects, which may be a stimulant or, more commonly, a depressant, depending on individual variation. # Anticholinergic, antiparkinsonian effect, which is used to treat acute dystonic reactions to antipsychotic drugs (Haldol, Thorazine, Compazine, etc.). These reactions include oculogyric crisis..."

2022-04-04T03:29:09Z

Created page with "'''Class''' Antihistamine '''Pharmacology and Actions''' # An antihistamine that blocks action of histamine released from the cells during an allergic reaction. # Direct CNS effects, which may be a stimulant or, more commonly, a depressant, depending on individual variation. # Anticholinergic, antiparkinsonian effect, which is used to treat acute dystonic reactions to antipsychotic drugs (Haldol, Thorazine, Compazine, etc.). These reactions include oculogyric crisis..."

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'''Class'''

Antihistamine

'''Pharmacology and Actions'''

# An antihistamine that blocks action of histamine released from the cells during an allergic reaction.
# Direct CNS effects, which may be a stimulant or, more commonly, a depressant, depending on individual variation.
# Anticholinergic, antiparkinsonian effect, which is used to treat acute dystonic reactions to antipsychotic drugs (Haldol, Thorazine, Compazine, etc.). These reactions include oculogyric crisis, acute torticollis, and facial grimacing.

'''Indications'''

# Moderate allergic reaction.
# The second-line drug in anaphylaxis and severe allergic reactions (after epinephrine).
# To prevent or counteract extrapyramidal reactions from antipsychotic medications.
# For use in intractable vomiting.

'''Contraindications'''

# Asthma (relative)
# Nursing mothers

'''Precautions'''

# May have additive effect with alcohol or depressants.

'''Administration'''

# Adult: 25 mg slow IV/IO push or 50 mg IM
# Children 8 years and younger: 1 mg/kg slow IV (not to exceed 25 mg total).

'''Side Effects and Special Notes'''

# May cause CNS stimulation in children.
# Side effects include dry mouth, dilated pupils, flushing, and drowsiness.
# Diphenhydramine should be used with caution in patients with asthma/COPD, glaucoma, and bladder obstruction, as all of these conditions can be exacerbated by its administration.
# If an IV has been or will be established for other reasons, the IV route is preferred over the IM route.

DIPHENHYDRAMINE (BENADRYL) - Revision history