Cgabryszek: Created page with "'''Class''' Antiarrhythmic '''Pharmacology and Actions''' # Adenosine is an endogenous nucleoside with antiarrhythmic activity. # Because of its short plasma half-life (less than 10 seconds with IV doses), the clinical effects of adenosine occur rapidly and are very brief. # Produces a transient slowing of the sinus rate # Has a depressant effect on the AV node. '''Indications''' # For termination of episodes of acute supraventricular tachycardia involving the AV-no..."

2022-04-04T03:15:26Z

Created page with "'''Class''' Antiarrhythmic '''Pharmacology and Actions''' # Adenosine is an endogenous nucleoside with antiarrhythmic activity. # Because of its short plasma half-life (less than 10 seconds with IV doses), the clinical effects of adenosine occur rapidly and are very brief. # Produces a transient slowing of the sinus rate # Has a depressant effect on the AV node. '''Indications''' # For termination of episodes of acute supraventricular tachycardia involving the AV-no..."

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'''Class'''

Antiarrhythmic

'''Pharmacology and Actions'''

# Adenosine is an endogenous nucleoside with antiarrhythmic activity.
# Because of its short plasma half-life (less than 10 seconds with IV doses), the clinical effects of adenosine occur rapidly and are very brief.
# Produces a transient slowing of the sinus rate
# Has a depressant effect on the AV node.

'''Indications'''

# For termination of episodes of acute supraventricular tachycardia involving the AV-node.

'''Contraindications'''

# Second or third-degree heart block
# Sick sinus syndrome
# Known hypersensitivity to drug

'''Precautions'''

# Adverse effects include hypotension, flushing, dyspnea, chest pain, anxiety, and occasionally, hemodynamic disturbances - all of which are of short duration.
# Transient arrhythmias including asystole and blocks are common at the time of chemical cardioversion.

'''Administration'''

# Direct rapid intravenous bolus over 1-2 seconds of 6mg initially, followed immediately by 20mL saline flush. A second dose of 12 mg may be given after an interval of 1-2 minutes if the tachycardia persists.
# Pediatric dose: rapid IV 0.1 mg/kg IV/IO initial dose followed immediately with a saline flush (greater than 5mL). Second dose 0.2 mg/kg rapid IV/IO if SVT persists. Maximum first dose is 6 mg. Maximum second dose is 12mg.

'''Side Effects and Notes'''

# Whenever possible, establish the IV at the antecubital
# Adenosine is safe in patients with Wolff Parkinson-White Syndrome.
# Concomitant use of dipyridamole (Persantine) enhances the effects of adenosine. Smaller doses may be required.
# Caffeine and theophylline antagonize adenosine's effects. Larger doses may be required.
# Warn patients to expect a brief sensation of chest discomfort.
# If patient becomes hemodynamically unstable, see appropriate tachycardia algorithm.
# Stable, asymptomatic patients, without a history of PSVT, may not need to be treated.
# Any patient receiving adenosine must be on a monitor and a 12-lead EKG should be performed and documented, if available.

ADENOSINE (ADENOCARD) - Revision history